Australia’s Human Research Ethics Committees (HREC) cleared first-in-human study of drug candidate PLL001. PLL001 aims at restoring microbiome and stopping gut from leaking to treat root cause of ALS, not solely symptoms...
Dr. Kechairi strengthens clinical team to advance PLL Therapeutics’ autoimmune and neurodegenerative diseases pipeline and enter phase 1 clinical trials with lead candidate for Amyotrophic Lateral Sclerosis (ALS)...
The intestine is well known to be our second brain and nearly 500 million neurons line our intestine (20 times less than our brain). But in the history of humanity was not the intestine our first Brain? The first primitive organisms were a simple digestive tract!...
The safety of PLL001 was evaluated in vivo in SOD1 mice treated or. This study was carried out in 60 mice split 4 groups (WT vehicle group1, SOD1 vehicle group 2, SOD1 Low Dose group 3 and SOD1 High Dose group 4). The low dose was estimated to be equivalent of the foreseen clinical dose and the high dose was 10 folds higher....
More and more the Gut is highlighted in many diseases as playing a key role in Parkinson or ALS by being the open gate for many components as bacteria, fungal element, lipopolysaccharides (LPS), toxins and chemicals to move in the blood and in the brain which can have a role in the development of the disease and in its chronicity....